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However, certain groups should exercise caution

Biochemistry (Mosc) (2013) 78:11126.10.1134/S0006297913020016 35 HeissEHerhausCKlimoKBartschHGerhauserC

422 In addition to Smad-dependent pathways, TGF- can also activate liver fibrosis via noncanonical (non-Smad) pathways such as MAPK, mTOR, PI3K/Akt, IKK, Wnt/-catenin, and Rho GTPase pathways